Ha G, Roth A, Lai D, Bashashati A, Ding J, Goya R, Giuliany R, Rosner J, Oloumi A, Shumansky K, Chin SF, Turashvili G, Hirst M, Caldas C, Marra MA, Aparicio S, Shah SP. Integrative analysis of genome-wide loss of heterozygosity and mono-allelic expression at nucleotide resolution reveals disrupted pathways in triple negative breast cancer. Genome Research 2012, advance online publication. Download paper
For this work, we also developed a probabilistic tool, called APOLLOH, for analyzing loss of heterozygosity (LOH) in whole genome sequencing of tumour-normal data.